“There is an integrative ventilatory, cardiovascular and metabolic physiological response to chronic hypercapnia. Chronic hypercapnia leads to deterioration of cognitive function.” J Physiol. 2018 Nov;596(22):5343-5363. doi: 10.1113/JP276666. Epub 2018 Oct 14. Ventilatory and integrated physiological responses to chronic hypercapnia in goats Nicholas J Burgraff 1, Suzanne E Neumueller 1, Kirstyn Buchholz 1, Thomas M Langer 3rd 1, Matthew R Hodges 1 2, Lawrence Pan 3, Hubert V Forster 1 2 4
Paula and I think that the signs and symptoms of the bipolar depressive/mixed/manic syndrome are stages of the “integrative ventilatory, cardiovascular and metabolic physiological response to chronic hypercapnia.” We think shorter episodes of delirium [ quiet, mixed, wild locomotor subtypes] are the same stages of the “integrative ventilatory, cardiovascular and metabolic physiological response to chronic hypercapnia.“
Paula and I think that this integrated response is what Dr Kraepelin reported in his patients with obvious ventilatory defects causing attacks of manic depressive insanity after ill health or exposure to emissions that cause acid base issues, specifically involving CO2 in the blood or triggering some gas-transmitters in this crisis.
Please look at the blog post where we report her lung function test result on respiratory rate and tidal volume in health and what it suggests; please look at Injury to the Ventilatory System; Paula’s Test Results to understand what we are currently discovering.
to be continued;