Loss of Eupnea

Eupnea is defined as normal relaxed breathing at rest. Paula has lost this ability, that is what counting her baseline respiratory rate at rest indicates. She probably sustained this focal damage at birth, when she was born not breathing [from having swallowed meconium]. Other latent pathways must have been activated when she was revived. At… Continue reading Loss of Eupnea


Hidden Injury to Key Spinal interneurons in Bipolar Illness?

from an email written to a researcher about my thoughts on this subject: Here are some references to current papers that I found on  sleep deprivation and effects on the motor act of breathing.....[which involves communication between the neurons of the brainstem and the neurons and neuronal  fibres of the spinal cord, something which I… Continue reading Hidden Injury to Key Spinal interneurons in Bipolar Illness?

My Hypothesis:

I suggest to you that ..... ..... anhedonia, depression, euphoria, anxiety, migraine, initial loss of weight, malaise, paranoia, delusions, hallucinations, mania, cognitive impairment, motor activity and speed changes, and changes to the autonomic nervous system vital signs are neurotoxic symptoms,  same as the neurotoxic symptoms seen with different levels of intoxication or poisoning.  And I think that all… Continue reading My Hypothesis:

The Impact of Sleep Deprivation on the Respiratory Muscles

Am J Respir Crit Care Med  2020 Apr 15;201(8):976-983.  doi: 10.1164/rccm.201904-0819OC. Impact of Sleep Deprivation on Respiratory Motor Output and Endurance. A Physiological Study Christophe Rault 1 2, Aude Sangaré 3, Véronique Diaz 1 2, Stéphanie Ragot 1 4, Jean-Pierre Frat 1 5, Mathieu Raux 6 7, Thomas Similowski 6 8, René Robert 1 5, Arnaud W Thille 1 5, Xavier Drouot 1 2 3 9 PMID: 31810378 DOI: 10.1164/rccm.201904-0819OC Free article Abstract Rationale: Sleep deprivation can alter endurance of skeletal muscles, but its impact on respiratory command… Continue reading The Impact of Sleep Deprivation on the Respiratory Muscles

The Patterns and Signs of Neuro-Toxicity

for exogenous poisons and intoxicants are THE SAME as those of serious mental disorders such as bipolar illness and schizophrenia and other dementias; severe depression, unexplained continuous fear and anxiety, loss of appetite, involuntary loss of weight, inability to sleep, malaise, fatigue, motor slowing, motor excitement and hyperactivity, paranoia, hallucinations,psychosis, delirium, dementia, altered mental status....all… Continue reading The Patterns and Signs of Neuro-Toxicity

Looking for the Pathophysiology of Severe Mental Illnesses

Trying to find a magic pill without exploring the pathophysiology of adult onset disturbance of mind, mood and motor activity is unlikely to succeed and blind attempts to try , may cause damage and impede recovery. Antipsychotics may make patients more manageable but do not restore their original baseline adult function . Without their original… Continue reading Looking for the Pathophysiology of Severe Mental Illnesses

When the Brain is not able to function at its full capacity

then we get patterns and levels of dysfunction that interfere with our higher cognitive abilities. It is not enough for the brain to only manage the autonomic nervous system because the ANS does not interact with the environment; the executive functions are needed to provide outside feedback and allowing for complex purposeful movement. to be… Continue reading When the Brain is not able to function at its full capacity

Does Serotonin work by adjusting pH of the blood?

If Paula and other manic depressives do have set points for breathing rates at rest that are too low [during bipolar] depressive attacks, then this begs the question of whether their pH is normal during attacks of depression. And if the respiratory depression of the breathing rate also affects the negative feedback mechanism [think about… Continue reading Does Serotonin work by adjusting pH of the blood?

Homeostasis is the key

to normal consciousness and normal emotional responses and to normal function of the brain and its higher functions. It is that simple. And that complex. And "a patient's vital signs (blood pressure, core body temperature, heart rate, respiratory rate, and oxygen saturation) are the first measurement indicating if there is a homeostatic imbalance. " https://www.ncbi.nlm.nih.gov/books/NBK559138/ PHYSIOLOGY;HOMEOSTASIS:… Continue reading Homeostasis is the key