“Integrated Host Response” to Respiratory Hypercapnia Acidosis

To understand our ongoing ideas mind and loss of mind and the role of PCO2 and hypercapnia,   please look at our post on     *** a Potential two Step Marker for Bipolar Depressive Illness [to start] and our post on      *** How to Save a Manic Depressive Life.

1] https://ofsoundmind.life/2020/11/09/we-have-a-2-step-marker-for-bipolar-illness/ We have a potential new 2 step biomarker for bipolar illness. Ventilatory issues and [hidden] hypercapnia can cause specific patterns of “odd behaviour”, mood and locomotor activity.    


2]  https://ofsoundmind.life/2020/11/11/how-to-save-a-manic-depressives-life/

At the very least!

Paula and I have identified a ventilatory injury/defect in that I can be most clearly identified in the  depressive stage of manic depressive insanity.  Kraepelin seems to have identified the same injury/defect over 100+ years ago. This is what is guiding us to new research to connect the dots. It is a lot of fun. It is something that scientists can follow up on. And we think this will make a huge difference in the new updated understanding of the reversible syndrome of bipolar illness and its treatment. this is how we have gotten to learn about adenosine and its ability to inhibit respiration rate in the face of hypercapnia……

Physiological effects of hyperchloraemia and acidosis J. M. Handy, N. Soni BJA: British Journal of Anaesthesia, Volume 101, Issue 2, August 2008, Pages 141–150, https://doi.org/10.1093/bja/aen148     Published: 04 June 2008……Significant snippets to be aware of re: this topic!!!!!!…”clinical application of in vitro data is flawed. In nature, acidosis inevitably results in an integrated host response that encompasses far more than the metabolic functions of the cell…….Teleology…

Acidosis is a common occurrence in mammals. Indeed, any burst of exercise results in an acidosis and the ability of mammals to recover from extreme exercise and from pathophysiological acidosis of respiratory and metabolic origin is impressive…… ……Although the disease state may be different, there is little doubt that normal mammalian physiology is designed to deal with acidosis, at least initially. It is worth considering this approach further through the rigorously studied model of exercise physiology……. the combined effects of acidosis concurrent with associated metabolic alterations in the whole organism may be markedly different from those seen in isolated preparations……….Exercise: a physiological model of acidosis“.

to be continued…..

to be continued….


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