This begins to explain creatures like Paula, who have experienced anoxia, swallowing meconium and hyperpnea and foreign blood products at birth , thus receiving much needed help in transitioning from an aquatic environment [the womb] to one in which breathing air is required.
You MUST read this paper!
Front Biol. Author manuscript; available in PMC 2012 Aug 6.Published in final edited form as:Front Biol. 2012 Jun; 7(3): 246–253. doi: 10.1007/s11515-012-1219-xPMCID: PMC3412401NIHMSID: NIHMS394474PMID: 22876258
The neurobiology of sensing respiratory gases for the control of animal behavior
This explains the changes in Paula allowing her to exchange only 1.5 L of air instead of 6-8 L [minute ventilation]…see previous blog posts dealing with this.
Genes are turned on and off at birth depending on what the newborn is exposed to during the transition to breathing air and swallowing liquids for the first time. Paula did not take her first breath. She required suctioning of meconium, resuscitation and a blood transfusion in order to survive her first moments, minutes and hours.
This explains why she has an [acquired?] respiratory defect. It explains why she was not aware of it.
The explains [possibly] why Dr Kraepelin found thousands of people with the same respiratory defect. And they were not aware of it either.
This is why counting respiratory rate and tidal volume is KEY to understanding some diseases.
This explains why some very serious illnesses are reversible, depending on PCO2 internal levels.
This explains unexpected mutations and why they endure.
This explains how to unmask and rescue some critically ill patients by understanding patterns of vital signs, respiratory rate [and if possible tidal volume], heart rate, blood pressure and body temperature and presence or absence of altered mental and physical status.
This explains abnormal and frightening signs of hidden stages of “internal suffocation” in people who suddenly become unable to state what is wrong with them. Internal suffocation will affect behaviour and the behaviour will mimc their abnormal breathing rate. Too slow breathing [due to respiratory defect during illness will produce slowed mental status, diminished locomotor activity and speech and diminished feeding. Too fast and periodic breathing with signs of heart failure [in the same patient] will produce too fast
To be continued.